We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

Asheim, O. Om handlingsformidling.--Hellesnes, J. Hending, handling og aktør.--Apel, K.-O. Vår tids konflikter og muligheten for en etiskpolitisk grunnorientering.--Böhler, D. Å kunne handle, å kunne forstå, å kunne tale.--Nordenstam, T. Vetenskaplig kompetens.--Måseide, A. Perspektivitet, intensjonalitet, refleksjon.--Øfsti, A. Moral og erscheinungswelt hos Kant.--Haga, Å. Transcendentalfilosofi og refleksiv argumentasjon.--Skirbekk, G. Folkelege tankar om sikt og oversikt.--Johannessen, K. S. Mening, kontekst, praksis og transcendentalitet.--Kalleberg, R. Fra kritikk av positivismen til kritikk av kapitalismens politiske økonomi.--Slagstad, R. Struktur-funksjonalisme og historisk materialisme.--Wyller, E. A. Politisk oppløsning (...) og forfall ifølge Platon.--Høibraaten, H. Romantisk eller teknologisk refleksjon. (shrink)

In 1954 F. R. Leavis wrote to the Times Literary Supplement taking issue with one of its reviewers. The reviewer had contrasted Leavis's approach to Shakespeare with that of Empson and Bradley. The latter, the reviewer had said, ‘like the plain man, or the audience in a theatre, cannot help considering the situation [in one of Shakespeare's plays] as “actual” and the characters as “real”’. Leavis, the reviewer had implied, treats the situation and characters somewhat differently.

Book reviewed in this article:F.H. Bradley, Collected Works Volumes 1–5.

Philosophical Investigations, EarlyView.

Metaphysics -- Bacon -- Locke -- Kant -- Comte -- Logical positivism -- Russell -- Analysis -- Quine and science -- Wittgenstein.

In recent times Wittgenstein's work in logic has had an influence on other branches of philosophy. I am thinking, in particular, of social philosophy and the philosophy of religion. In these branches, Wittgenstein's followers have made much use of his notion of a language game. It has been argued, for example, that religion forms a language game of its own, having its own standards of reason, and is therefore not subject to criticism from outside. This argument has given rise to (...) controversy, some seeing it as a subtle attempt by the religious to evade criticism. I have come myself to feel that the notion of a language game has been put to uses with which Wittgenstein himself might not have agreed, or, if he had, would have been wrong to do so. In order to explain what I mean I should like to look closely at the opening section of Peter Winch's article ‘Understanding a Primitive Society’. (shrink)

ABSTRACT A number of philosophers have argued that alcoholics should receive lower priority for liver transplantations because they are morally responsible for their medical conditions. In this paper, I argue that this conclusion is false. Moral responsibility should not be used as a criterion for the allocation of medical resources. The reason I advance goes further than the technical problem of assessing moral responsibility. The deeper problem is that using moral responsibility as an allocation criterion undermines the functioning of medicine.

Nocebo effects occur when an individual experiences undesirable physiological reactions caused by doxastic states that are not a treatment’s core or characteristic features.1 As Scott Gelfand2 points out, there are numerous studies that have shown that the disclosure of a treatment’s side effects to a patient increases the risk of the side effects. From an ethical point of view, nocebo effects caused by the disclosures of side effects present a challenging problem. On the one hand, clinicians’ duty to inform patients (...) of the consequences (including possible side effects) of their treatments is critical in ensuring that patients’ autonomy is respected. Patients cannot act autonomously if relevant information is withheld from them (without their consent, perhaps). On the other hand, clinicians also ought to minimize harm to patients. (shrink)

_Hume's Naturalism_ provides a clear and concise guide to the debates over whether Hume's empiricism or his 'naturalism' in the tradition of the Scottish 'Common Sense' school of philosophy gained his upper hand. This debate is central to any understanding of Hume's thought. H.O. Mounce presents a beautifully clear guide to Hume's most important works, _The Treatise on Human Nature_ and _Dialogues Concerning Natural Religion_. Accessible to anyone coming to Hume for the first time, _Hume's Naturalism_ affords a much needed (...) overview of the key concepts of empiricism, causation, scepticism, reason and morality that are essential to any understanding of Hume's philosophy. (shrink)